Diabetes-Associated Sustained Activation of the Transcription Factor Nuclear Factor- B
نویسندگان
چکیده
منابع مشابه
Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB.
Activation of the transcription factor nuclear factor-kappaB (NF-kappaB) has been suggested to participate in chronic disorders, such as diabetes and its complications. In contrast to the short and transient activation of NF-kappaB in vitro, we observed a long-lasting sustained activation of NF-kappaB in the absence of decreased IkappaBalpha in mononuclear cells from patients with type 1 diabet...
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In contrast to nuclear factorB (NFB) activation by tumor necrosis factor(TNF), the specific processes involved in the activation of this transcription factor by ionizing radiation (IR) have not been completely defined. According to the classical paradigm, a critical event in NFB activation is the degradation of I B . Data presented herein show that, in contrast to treatment with TNF, IR-induced...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2001
ISSN: 0012-1797,1939-327X
DOI: 10.2337/diabetes.50.12.2792